acrivastine and lorazepam both increase sedation. Use Caution/Monitor.
lorazepam increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
lorazepam and alfentanil both increase sedation. Use Caution/Monitor.
alprazolam and lorazepam both increase sedation. Use Caution/Monitor.
amisulpride and lorazepam both increase sedation. Use Caution/Monitor.
lorazepam and amitriptyline both increase sedation. Use Caution/Monitor.
amobarbital and lorazepam both increase sedation. Use Caution/Monitor.
lorazepam and amoxapine both increase sedation. Use Caution/Monitor.
lorazepam increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
lorazepam and apomorphine both increase sedation. Use Caution/Monitor.
lorazepam increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
lorazepam and aripiprazole both increase sedation. Use Caution/Monitor.
lorazepam increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
asenapine and lorazepam both increase sedation. Use Caution/Monitor.
asenapine transdermal and lorazepam both increase sedation. Use Caution/Monitor.
avapritinib and lorazepam both increase sedation. Use Caution/Monitor.
azelastine and lorazepam both increase sedation. Use Caution/Monitor.
lorazepam and baclofen both increase sedation. Use Caution/Monitor.
lorazepam and belladonna and opium both increase sedation. Use Caution/Monitor.
lorazepam and benperidol both increase sedation. Use Caution/Monitor.
lorazepam increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
brexanolone, lorazepam.Either increases toxicity of the other by sedation. Use Caution/Monitor.
brexpiprazole and lorazepam both increase sedation. Use Caution/Monitor.
brimonidine and lorazepam both increase sedation. Use Caution/Monitor.
brivaracetam and lorazepam both increase sedation. Use Caution/Monitor.
brompheniramine and lorazepam both increase sedation. Use Caution/Monitor.
lorazepam and buprenorphine both increase sedation. Use Caution/Monitor.
lorazepam and buprenorphine buccal both increase sedation. Use Caution/Monitor.
lorazepam increases toxicity of buprenorphine subdermal implant by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Studies have shown that the combination of benzodiazepines and buprenorphine altered the usual ceiling effect on buprenorphine-induced respiratory depression, making the respiratory effects of buprenorphine appear similar to those of full opioid agonists. There have been postmarketing reports of coma and death with coadministration of buprenorphine and benzodiazepines. In many, but not all of these cases, buprenorphine was misused by self-injection. If a benzodiazepine must be used for an indication other than seizures, lower the benzodiazepine initial dose and cautiously titrate to clinical response.
lorazepam increases toxicity of buprenorphine, long-acting injection by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of buprenorphine and benzodiazepines or other CNS depressants increases risk of adverse reactions including overdose, respiratory depression, and death. Cessation of benzodiazepines or other CNS depressants is preferred in most cases. In some cases, monitoring at a higher level of care for tapering CNS depressants may be appropriate. In others, gradually tapering a patient off of a prescribed benzodiazepine or other CNS depressant or decreasing to the lowest effective dose may be appropriate.
butabarbital and lorazepam both increase sedation. Use Caution/Monitor.
butalbital and lorazepam both increase sedation. Use Caution/Monitor.
lorazepam and butorphanol both increase sedation. Use Caution/Monitor.
lorazepam increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
cannabidiol will increase the level or effect of lorazepam by decreasing metabolism. Modify Therapy/Monitor Closely. Cannabidiol may potentially inhibit UGT2B7 activity. Consider reducing the dose when concomitantly using UGT2B7 substrates.
carbinoxamine and lorazepam both increase sedation. Use Caution/Monitor.
cariprazine and lorazepam both increase sedation. Use Caution/Monitor.
lorazepam and carisoprodol both increase sedation. Use Caution/Monitor.
cenobamate, lorazepam.Either increases effects of the other by sedation. Use Caution/Monitor.
lorazepam and chloral hydrate both increase sedation. Use Caution/Monitor.
chlordiazepoxide and lorazepam both increase sedation. Use Caution/Monitor.
chlorpheniramine and lorazepam both increase sedation. Use Caution/Monitor.
lorazepam and chlorpromazine both increase sedation. Use Caution/Monitor.
lorazepam and chlorzoxazone both increase sedation. Use Caution/Monitor.
cinnarizine and lorazepam both increase sedation. Use Caution/Monitor.
clemastine and lorazepam both increase sedation. Use Caution/Monitor.
lorazepam, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression).
lorazepam and clomipramine both increase sedation. Use Caution/Monitor.
clonazepam and lorazepam both increase sedation. Use Caution/Monitor.
clonidine, lorazepam.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration enhances CNS depressant effects.
clorazepate and lorazepam both increase sedation. Use Caution/Monitor.
lorazepam and clozapine both increase sedation. Use Caution/Monitor.lorazepam, clozapine. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Possible risk of cardiorespiratory collapse.
lorazepam and codeine both increase sedation. Use Caution/Monitor.
cyclizine and lorazepam both increase sedation. Use Caution/Monitor.
lorazepam and cyclobenzaprine both increase sedation. Use Caution/Monitor.
cyproheptadine and lorazepam both increase sedation. Use Caution/Monitor.
lorazepam and dantrolene both increase sedation. Use Caution/Monitor.
lorazepam and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychom*otor performance and cause daytime impairment.
desflurane and lorazepam both increase sedation. Use Caution/Monitor.
lorazepam and desipramine both increase sedation. Use Caution/Monitor.
desloratadine and lorazepam both increase sedation. Use Caution/Monitor.
lorazepam and deutetrabenazine both increase sedation. Use Caution/Monitor.
dexchlorpheniramine and lorazepam both increase sedation. Use Caution/Monitor.
lorazepam increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
lorazepam and dexmedetomidine both increase sedation. Use Caution/Monitor.
lorazepam increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
lorazepam increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
lorazepam and dextromoramide both increase sedation. Use Caution/Monitor.
lorazepam and diamorphine both increase sedation. Use Caution/Monitor.
diazepam and lorazepam both increase sedation. Use Caution/Monitor.
diazepam buccal and lorazepam both increase sedation. Use Caution/Monitor.diazepam buccal, lorazepam.Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.
diazepam intranasal, lorazepam.Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.diazepam intranasal and lorazepam both increase sedation. Use Caution/Monitor.
dichlorphenamide, lorazepam.Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Both drugs can cause metabolic acidosis.
lorazepam increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
difelikefalin and lorazepam both increase sedation. Use Caution/Monitor.
lorazepam and difenoxin hcl both increase sedation. Use Caution/Monitor.
dimenhydrinate and lorazepam both increase sedation. Use Caution/Monitor.
diphenhydramine and lorazepam both increase sedation. Use Caution/Monitor.
lorazepam and diphenoxylate hcl both increase sedation. Use Caution/Monitor.
lorazepam and dipipanone both increase sedation. Use Caution/Monitor.
lorazepam increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
lorazepam increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
lorazepam increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
lorazepam and dosulepin both increase sedation. Use Caution/Monitor.
lorazepam and doxepin both increase sedation. Use Caution/Monitor.
lorazepam and doxylamine both increase sedation. Use Caution/Monitor.
lorazepam and droperidol both increase sedation. Use Caution/Monitor.
lorazepam increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
lorazepam increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
lorazepam increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
esketamine intranasal, lorazepam.Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.
estazolam and lorazepam both increase sedation. Use Caution/Monitor.
lorazepam and ethanol both increase sedation. Use Caution/Monitor.
etomidate and lorazepam both increase sedation. Use Caution/Monitor.
lorazepam increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
lorazepam and flibanserin both increase sedation. Modify Therapy/Monitor Closely. Risk for sedation increased if flibanserin is coadministration with other CNS depressants.
lorazepam and fluphenazine both increase sedation. Use Caution/Monitor.
flurazepam and lorazepam both increase sedation. Use Caution/Monitor.
lorazepam increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
gabapentin, lorazepam.Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.
gabapentin enacarbil, lorazepam.Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.
lorazepam and ganaxolone both increase sedation. Use Caution/Monitor.
lorazepam and haloperidol both increase sedation. Use Caution/Monitor.
hyaluronidase, lorazepam. Other (see comment). Use Caution/Monitor. Comment: Drug combination has been found to be incompatible.
lorazepam and hydromorphone both increase sedation. Use Caution/Monitor.
hydroxyzine and lorazepam both increase sedation. Use Caution/Monitor.
lorazepam and iloperidone both increase sedation. Use Caution/Monitor.
lorazepam and imipramine both increase sedation. Use Caution/Monitor.
lorazepam increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
ketamine and lorazepam both increase sedation. Use Caution/Monitor.
lorazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
lasmiditan, lorazepam.Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.
lemborexant, lorazepam.Either increases effects of the other by sedation. Modify Therapy/Monitor Closely. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects.
lorazepam increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
levetiracetam and lorazepam both increase sedation. Use Caution/Monitor.
levocetirizine and lorazepam both increase sedation. Use Caution/Monitor.
lorazepam and levorphanol both increase sedation. Use Caution/Monitor.
lorazepam increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
lorazepam and lofepramine both increase sedation. Use Caution/Monitor.
lorazepam and lofexidine both increase sedation. Use Caution/Monitor.
loprazolam and lorazepam both increase sedation. Use Caution/Monitor.
loratadine and lorazepam both increase sedation. Use Caution/Monitor.
lorazepam and lormetazepam both increase sedation. Use Caution/Monitor.
lorazepam and loxapine both increase sedation. Use Caution/Monitor.lorazepam, loxapine. Mechanism: unknown. Use Caution/Monitor. Risk of resp. depression, hypotension.
lorazepam and loxapine inhaled both increase sedation. Use Caution/Monitor.lorazepam, loxapine inhaled. Mechanism: unknown. Use Caution/Monitor. Risk of resp. depression, hypotension.
lumateperone and lorazepam both increase sedation. Use Caution/Monitor.
lurasidone, lorazepam.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity.
lorazepam and maprotiline both increase sedation. Use Caution/Monitor.
lorazepam and marijuana both increase sedation. Use Caution/Monitor.
lorazepam and melatonin both increase sedation. Use Caution/Monitor.
lorazepam and meperidine both increase sedation. Use Caution/Monitor.
lorazepam and meprobamate both increase sedation. Use Caution/Monitor.
lorazepam increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
lorazepam and metaxalone both increase sedation. Use Caution/Monitor.
lorazepam and methadone both increase sedation. Use Caution/Monitor.
lorazepam increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
lorazepam and methocarbamol both increase sedation. Use Caution/Monitor.
lorazepam increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
methylphenidate transdermal will increase the level or effect of lorazepam by decreasing metabolism. Modify Therapy/Monitor Closely. Consider decreasing the dose of these drugs when given coadministered with methylphenidate. Monitor for drug toxiticities when initiating or discontinuing methylphenidate.
lorazepam and midazolam both increase sedation. Use Caution/Monitor.
midazolam intranasal, lorazepam.Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.
lorazepam increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
lorazepam and mirtazapine both increase sedation. Use Caution/Monitor.
lorazepam increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
lorazepam and morphine both increase sedation. Use Caution/Monitor.
lorazepam and motherwort both increase sedation. Use Caution/Monitor.
lorazepam and moxonidine both increase sedation. Use Caution/Monitor.
lorazepam and nabilone both increase sedation. Use Caution/Monitor.
lorazepam and nalbuphine both increase sedation. Use Caution/Monitor.
lorazepam increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
lorazepam and nortriptyline both increase sedation. Use Caution/Monitor.
lorazepam and olanzapine both increase sedation. Use Caution/Monitor.
lorazepam, olanzapine/samidorphan.Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration of diazepam, alcohol, or other CNS acting drugs may potentiate orthostatic hypotension observed with olanzapine. Additive sedation may also occur.
oliceridine, lorazepam.Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
lorazepam and opium tincture both increase sedation. Use Caution/Monitor.
orlistat decreases levels of lorazepam by inhibition of GI absorption. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Risk of convulsions.
lorazepam and orphenadrine both increase sedation. Use Caution/Monitor.
lorazepam and oxazepam both increase sedation. Use Caution/Monitor.
lorazepam and oxycodone both increase sedation. Use Caution/Monitor.
lorazepam and oxymorphone both increase sedation. Use Caution/Monitor.
lorazepam and paliperidone both increase sedation. Use Caution/Monitor.
lorazepam and papaveretum both increase sedation. Use Caution/Monitor.
lorazepam and papaverine both increase sedation. Use Caution/Monitor.
lorazepam and pentazocine both increase sedation. Use Caution/Monitor.
pentobarbital and lorazepam both increase sedation. Use Caution/Monitor.
perampanel and lorazepam both increase sedation. Use Caution/Monitor.
lorazepam and perphenazine both increase sedation. Use Caution/Monitor.
lorazepam increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
phenobarbital and lorazepam both increase sedation. Use Caution/Monitor.
lorazepam increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
lorazepam increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
lorazepam increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
lorazepam and pholcodine both increase sedation. Use Caution/Monitor.
lorazepam and pimozide both increase sedation. Use Caution/Monitor.
lorazepam increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
pregabalin, lorazepam.Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.
primidone and lorazepam both increase sedation. Use Caution/Monitor.
lorazepam and prochlorperazine both increase sedation. Use Caution/Monitor.
promethazine and lorazepam both increase sedation. Use Caution/Monitor.
propofol and lorazepam both increase sedation. Use Caution/Monitor.
lorazepam increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
lorazepam and protriptyline both increase sedation. Use Caution/Monitor.
lorazepam and quazepam both increase sedation. Use Caution/Monitor.
lorazepam and quetiapine both increase sedation. Use Caution/Monitor.
lorazepam and ramelteon both increase sedation. Use Caution/Monitor.
remimazolam, lorazepam.Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Continuously monitor vital signs during sedation and recovery period if coadministered. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics.
lorazepam and risperidone both increase sedation. Use Caution/Monitor.
lorazepam increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
lorazepam and scullcap both increase sedation. Use Caution/Monitor.
secobarbital and lorazepam both increase sedation. Use Caution/Monitor.
sevelamer decreases levels of lorazepam by increasing elimination. Use Caution/Monitor.
sevoflurane and lorazepam both increase sedation. Use Caution/Monitor.
lorazepam and shepherd's purse both increase sedation. Use Caution/Monitor.
stiripentol, lorazepam.Either increases effects of the other by sedation. Use Caution/Monitor. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence.
lorazepam and sufentanil both increase sedation. Use Caution/Monitor.
suvorexant and lorazepam both increase sedation. Modify Therapy/Monitor Closely. Dosage adjustments of suvorexant and concomitant CNS depressants may be necessary
lorazepam and tapentadol both increase sedation. Use Caution/Monitor.
teduglutide increases levels of lorazepam by Other (see comment). Use Caution/Monitor. Comment: Teduglutide may increase absorption of concomitant PO medications; caution with with drugs requiring titration or those with a narrow therapeutic index; dose adjustment may be necessary.
lorazepam and temazepam both increase sedation. Use Caution/Monitor.
lorazepam increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
lorazepam and thioridazine both increase sedation. Use Caution/Monitor.
lorazepam and thiothixene both increase sedation. Use Caution/Monitor.
lorazepam and topiramate both increase sedation. Modify Therapy/Monitor Closely.
lorazepam and tramadol both increase sedation. Use Caution/Monitor.
lorazepam and trazodone both increase sedation. Use Caution/Monitor.
lorazepam and triazolam both increase sedation. Use Caution/Monitor.
lorazepam and triclofos both increase sedation. Use Caution/Monitor.
lorazepam and trifluoperazine both increase sedation. Use Caution/Monitor.
lorazepam and trimipramine both increase sedation. Use Caution/Monitor.
triprolidine and lorazepam both increase sedation. Use Caution/Monitor.
lorazepam increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
lorazepam increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
lorazepam and ziconotide both increase sedation. Use Caution/Monitor.
lorazepam and ziprasidone both increase sedation. Use Caution/Monitor.
lorazepam and zotepine both increase sedation. Use Caution/Monitor.
